Ultimate Comics: Spider-Man was a monthly comic book series published by Marvel Comics that debuted in September 2011 as part of the second re-launch of the Ultimate Marvel imprint. It followed the "Death of Spider-Man" storyline that concluded the series Ultimate Spider-Man, to which Ultimate Comics: Spider-Man served as a sequel. Written by Brian Michael Bendis and illustrated by Sara Pichelli, the series also served as a continuation of elements from the miniseries Ultimate Comics: Fallout and focuses on the all-new Spider-Man, Miles Morales. The series was set in a continuity shared with other relaunched Ultimate Marvel titles including Ultimate Comics: X-Men and Ultimate Comics: Ultimates. The title ended in October 2013; the adventures of Miles continue in Miles Morales: Ultimate Spider-Man, released in July 2014.

Ultimate Marvel, later known as Ultimate Comics, was an imprint of comic books published by Marvel Comics, featuring reimagined and modernized versions of the company's superhero characters from the Ultimate Marvel Universe, later known as the Ultimate Universe. Those characters include Spider-Man, the X-Men, the Ultimates, the Fantastic Four, and others. The imprint was launched in 2000 with the publication of the series Ultimate Spider-Man and Ultimate X-Men in 2001, followed by The Ultimates and Ultimate Fantastic Four in 2002 and 2004 respectively providing new origin stories for the characters. The reality of Ultimate Marvel is designated as Earth-1610 as part of the Marvel Comics Multiverse.