The United States House of Representatives Select Committee on Assassinations (HSCA) was established in 1976 to investigate the assassinations of John F. Kennedy and Martin Luther King Jr. in 1963 and 1968, respectively. The HSCA completed its investigation in 1978 and issued its final report the following year, which concluded that Kennedy was probably assassinated as a result of a conspiracy. In addition to now-discredited acoustic analysis of a police channel dictabelt recording, the HSCA also commissioned numerous other scientific studies of assassination-related evidence that corroborate the Warren Commission's findings.

On November 22, 1963, John F. Kennedy, the 35th president of the United States, was assassinated while riding in a presidential motorcade through Dealey Plaza in Dallas, Texas. Kennedy was in the vehicle with his wife, Jacqueline, Texas Governor John Connally, and Connally's wife, Nellie, when he was fatally shot from the nearby Texas School Book Depository by former U.S. Marine Lee Harvey Oswald. The motorcade rushed to Parkland Memorial Hospital, where Kennedy was pronounced dead about 30 minutes after the shooting; Connally was also wounded in the attack but recovered. Vice President Lyndon B. Johnson was hastily sworn in as president two hours and eight minutes later aboard Air Force One at Dallas Love Field.