The University Hospital of South Manchester NHS Foundation Trust is a defunct NHS foundation trust that previously operated Wythenshawe Hospital, a major acute teaching hospital in Wythenshawe, Manchester. Many of the services and facilities previously at Withington Hospital were transferred to Wythenshawe in 2004. It provided services for adults and children at Wythenshawe Hospital and Withington Community Hospital. It runs Buccleuch Lodge Intermediate Care Unit and the Dermot Murphy Centre in Withington, and the Specialised Ability Centre in Sharston.

Central Manchester University Hospital NHS Foundation Trust, was a large NHS foundation trust in Manchester, United Kingdom, that was founded in 2009 and merged with University Hospital of South Manchester NHS Foundation Trust in 2017 to form the current Manchester University NHS Foundation Trust.