The University of Alabama at Birmingham (UAB) is a public research university in Birmingham, Alabama. Founded in 1969 and part of the University of Alabama System, UAB has grown to be the state's largest employer, with more than 24,200 faculty and staff and over 53,000 jobs at the university. The university is classified among "R1: Doctoral Universities – Very high research activity".

Birmingham is a city in the north central region of Alabama. Birmingham is the county seat of Jefferson County, Alabama's most populous county. As of the 2022 census estimates, Birmingham had a population of 196,910, down 2% from the 2020 census, making it Alabama's third-most populous city after Huntsville and Montgomery. The broader Birmingham metropolitan area had a 2020 population of 1,115,289, and is the largest metropolitan area in Alabama as well as the 50th-most populous in the United States. Birmingham serves as an important regional hub and is associated with the Deep South, Piedmont, and Appalachian regions of the nation.