The University of Alabama at Birmingham Marnix E. Heersink School of Medicine is a public medical school located in Birmingham, Alabama, United States with branch campuses in Huntsville, Montgomery, and at the University of Alabama College of Community Health Sciences in Tuscaloosa. Residency programs are also located in Selma, Huntsville, and Montgomery. It is part of the University of Alabama at Birmingham (UAB).

Birmingham is a city in the north central region of Alabama. Birmingham is the county seat of Jefferson County, Alabama's most populous county. As of the 2022 census estimates, Birmingham had a population of 196,910, down 2% from the 2020 census, making it Alabama's third-most populous city after Huntsville and Montgomery. The broader Birmingham metropolitan area had a 2020 population of 1,115,289, and is the largest metropolitan area in Alabama as well as the 50th-most populous in the United States. Birmingham serves as an important regional hub and is associated with the Deep South, Piedmont, and Appalachian regions of the nation.