The University of the Philippines Manila College of Medicine (CM) is the medical school of the University of the Philippines Manila, the oldest constituent university of the University of the Philippines System. Its establishment in 1905 antedates the foundation of the UP System and makes it one of the oldest medical schools in the country. The Philippine General Hospital, the national university hospital, serves as its teaching hospital.

The Philippine General Hospital, simply referred to as UP–PGH or PGH, is a tertiary state-owned hospital administered and operated by the University of the Philippines Manila. It is designated as the National University Hospital, and the national government referral center. It stands within a 10-hectare (25-acre) site located at the UP Manila Campus in Ermita, Manila. PGH has 1,100 beds and 400 private beds, and has an estimated of 4,000 employees to serve more than 600,000 patients every year.