Uno Pizzeria & Grill, or more informally as Uno’s, is a United States-origin franchised pizzeria restaurant chain under the parent company Uno Restaurant Holdings Corporation. Uno Pizzeria and Grill is best known for its Chicago-style deep dish pizza. Ike Sewell opened the first Pizzeria Uno in 1940.

Chicago-style pizza is pizza prepared according to several styles developed in Chicago. It can refer to both the well-known deep-dish or stuffed pizzas and the lesser-known thin-crust tavern-style pizzas. The pan in which deep-dish pizza is baked gives the pizza its characteristically high edge, which provides ample space for large amounts of cheese and a chunky tomato sauce. Chicago-style deep-dish pizza may be prepared in the deep-dish style and as a stuffed pizza. Chicago-style thin-crust pizza dough is rolled for a thinner crispier crust than other thin-crust styles. The thin-crust pizza is cut in squares instead of slices, and is also referred to as a "tavern-style" pizza.