The Upper Mississippian cultures were located in the Upper Mississippi basin and Great Lakes region of the American Midwest. They were in existence from approximately A.D. 1000 until the Protohistoric and early Historic periods.

The Moccasin Bluff site is an archaeological site located along the Red Bud Trail and the St. Joseph River north of Buchanan, Michigan. It was listed on the National Register of Historic Places in 1977, and has been classified as a multi-component prehistoric site with the major component dating to the Late Woodland/Upper Mississippian period.