Upper Street is the main street of the Islington district of inner north London, and carries the A1 road. It begins at the junction of the A1 and Liverpool Road, continuing on from Islington High Street which runs from the crossroads at Pentonville Road/City Road and runs roughly northwards from outside the main entrance to Angel Underground station, then past the Business Design Centre, then splits at Islington Green, then past The Screen On The Green cinema, past Islington Town Hall, ending at Highbury & Islington tube station on Highbury corner, where the A1 carries on as Holloway Road.

Islington is a district in the north of Greater London, England, and part of the London Borough of Islington. It is a mainly residential district of Inner London, extending from Islington's High Street to Highbury Fields, encompassing the area around the busy High Street, Upper Street, Essex Road, and Southgate Road to the east.