Uptown is a section of New Orleans, Louisiana, United States, on the east bank of the Mississippi River, encompassing a number of neighborhoods between the French Quarter and the Jefferson Parish line. It remains an area of mixed residential and small commercial properties, with a wealth of 19th-century architecture. It includes part or all of Uptown New Orleans Historic District, which is listed on the National Register of Historic Places.

Uptown is a primarily residential neighborhood of the city of New Orleans. A subdistrict of the Uptown/Carrollton Area, its boundaries as defined by the New Orleans City Planning Commission are: LaSalle Street to the north, Napoleon Avenue to the east, Magazine Street to the south and Jefferson Avenue to the west.