Vancleave is an unincorporated community and census-designated place (CDP) in Jackson County, Mississippi, United States. It is part of the Pascagoula Metropolitan Statistical Area. The population was 5,886 at the 2010 census, up from 4,910 at the 2000 census.

Jackson County is a county located in the U.S. state of Mississippi. As of the 2020 census, the population was 143,252, making it the fifth-most populous county in Mississippi. Its county seat is Pascagoula. The county was named for Andrew Jackson, general in the United States Army and afterward President of the United States.