The vice-president of Ghana is the second-highest officer in the Government of Ghana. The vice-president, together with the President of Ghana, is directly elected by the people through popular vote to serve a four-year term in office. The vice-president is the first person in the presidential line of succession, and would ascend to the presidency upon the death, resignation, or removal of the president. The current vice-president is Mahamudu Bawumia, who took office on 7 January 2017, under President Nana Akufo-Addo.

The Government of Ghana was created as a parliamentary democracy, followed by alternating military and civilian governments in Ghana. In January 1993, military government gave way to the Fourth Republic after presidential and parliamentary elections in late 1992. The 1992 constitution divides powers among a president, parliament, cabinet, council of state, and an independent judiciary. The government is elected by universal suffrage.