The vice chief of staff of the Air Force (VCSAF) is the second-highest-ranking military officer in the United States Air Force. If the chief of staff of the Air Force (CSAF) is absent or is unable to perform his duties, then the VCSAF assumes the duties and responsibilities of the CSAF. The VCSAF may also perform other duties that the secretary of defense (SECDEF), the secretary of the Air Force (SECAF) or the CSAF assigns to him. The VCSAF is appointed by the president of the United States and must be confirmed via majority vote by the Senate. By statute, the VCSAF is appointed as a four-star general.

Nathan Farragut Twining was a United States Air Force general. He was the chief of Staff of the United States Air Force from 1953 until 1957, and the third chairman of the Joint Chiefs of Staff from 1957 to 1960. He was the first member of the Air Force to serve as Chairman. Twining was a distinguished "mustang" officer, rising from private to four-star general and appointment to the highest post in the United States Armed Forces in the course of his 45-year career.