State Route 69 is a primary state highway in the U.S. state of Virginia. Known as Lead Mine Road, the state highway runs 3.59 miles (5.78 km) from SR 636 in Austinville east to U.S. Route 52 in Poplar Camp. SR 69 is the last remnant of a much longer route. At its peak from 1940 to 1945, this route ran from State Route 91 at Lodi east via St. Clair Bottom, Sugar Grove, Cedar Springs, Speedwell, Porters Crossroads, and Austinville to today's SR 69. However, it was never fully continuous; portions from Sugar Grove to Cedar Springs and west of Porters Crossroads to east of Austinville were secondary routes. The full length of this route as it existed and was planned is now part of SR 762, part of SR 660, all of SR 650, part of SR 16, all of SR 614, part of SR 749, part of US 21, part of SR 690, a small piece of SR 642, part of SR 619, part of SR 636, and SR 69.

U.S. Route 52 in Virginia runs north–south through the southwestern part of the state along the Interstate 77 (I-77) corridor. Though an even-numbered U.S. route, it is signed north–south in Virginia. In some other states along its route, it is signed east–west. The Virginia segment is signed such that US 52 north corresponds to the general westward direction of the highway, and vice versa.