State Route 80 is a primary state highway in the southwest part of the U.S. state of Virginia. It runs from the Kentucky state line at Breaks Interstate Park east to U.S. Route 11 near Meadowview. Kentucky Route 80 and Missouri's Route 80 continue the number west to Matthews, Missouri. The entire length of SR 80 is part of U.S. Bicycle Route 76.

Breaks Interstate Park, also known as "the Breaks," is a bi-state state park located partly in southeastern Kentucky and southwestern Virginia in the Jefferson National Forest, at the northeastern terminus of Pine Mountain. The land is managed by an interstate compact between the states of Virginia and Kentucky. It is the only one of two interstate parks in the United States operated jointly under a compact rather than as two separate state park units. The Virginia Department of Conservation and Recreation and the Kentucky Department of Parks are still major partner organizations.