The Virginia Tech Hokies are the athletic teams representing Virginia Tech in intercollegiate athletics. The Hokies participate in the NCAA's Division I Atlantic Coast Conference in 22 varsity sports. Virginia Tech's men's sports are football, basketball, baseball, cross country, golf, soccer, swimming and diving, tennis, indoor and outdoor track and field, and wrestling. Virginia Tech's women's sports are basketball, cross country, lacrosse, soccer, softball, swimming and diving, tennis, indoor and outdoor track and field, golf, and volleyball.

The Virginia–Virginia Tech rivalry is an American college rivalry that exists between the Virginia Cavaliers sports teams of the University of Virginia and the Virginia Tech Hokies sports teams of Virginia Polytechnic Institute and State University. The Cavaliers and Hokies had a program-wide rivalry first called the Commonwealth Challenge (2005–2007) which UVA swept 2–0 before ending the series in a show of sportsmanship following the Virginia Tech massacre. A second series called the Commonwealth Clash (2014–2019), under revised rules and sponsored by the state's Virginia 529 College Savings Plan, was again won by UVA, 3–2. A third series, also called the Clash (2021–present) and sponsored by Smithfield Foods, emerged two years after the previous series was concluded and is currently tied, 1–1. The Cavaliers lead the rivalry series in the majority of sports.