The Virginia opossum, also known as the North American opossum, is the only opossum living north of Mexico, its range extending south into Central America. It is the northernmost marsupial in the world. In the United States and Canada, it is typically called a possum. It is a solitary nocturnal animal about the size of a domestic cat, and a successful opportunist.

Opossums are members of the marsupial order Didelphimorphia endemic to the Americas. The largest order of marsupials in the Western Hemisphere, it comprises 126 species in 18 genera. Opossums originated in South America and entered North America in the Great American Interchange following the connection of North and South America.