Vorpommern-Greifswald is a district in the east of Mecklenburg-Vorpommern, Germany. It is bounded by the districts of Mecklenburgische Seenplatte and Vorpommern-Rügen, the Baltic Sea, Poland and the state of Brandenburg. The district seat is the University and Hanseatic City of Greifswald. A lake called Berliner See is found in the district.

Greifswald, officially the University and Hanseatic City of Greifswald is the fourth-largest city in the German state of Mecklenburg-Western Pomerania after Rostock, Schwerin and Neubrandenburg. In 2021 it surpassed Stralsund for the first time, and became the largest city in the Pomeranian part of the state. It sits on the River Ryck, at its mouth into the Danish Wiek, a sub-bay of the Bay of Greifswald, which is itself a sub-bay of the Bay of Pomerania of the Baltic Sea.