The Waccamaw River is a river, approximately 140 miles (225 km) long, in southeastern North Carolina and eastern South Carolina in the United States. It drains an area of approximately 1,110 square miles (2886 km2) in the coastal plain along the eastern border between the two states into the Atlantic Ocean. Along its upper course, it is a slow-moving, blackwater river surrounded by vast wetlands, passable only by shallow-draft watercraft such as canoe. Along its lower course, it is lined by sandy banks and old plantation houses, providing an important navigation channel with a unique geography, flowing roughly parallel to the coast.

Georgetown is the third oldest city in the U.S. state of South Carolina and the county seat of Georgetown County, in the Lowcountry. As of the 2010 census it had a population of 9,163. Located on Winyah Bay at the confluence of the Black, Great Pee Dee, Waccamaw, and Sampit rivers, Georgetown is the second largest seaport in South Carolina, handling over 960,000 tons of materials a year, while Charleston is the largest.