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Walter Jakob Gehring (2014)
Walter Jakob Gehring (2014)
Drosophila Melanogaster, the object of Gehring's science (in which he studied genetics and development, particularly in the analysis of the embryo
Drosophila Melanogaster, the object of Gehring's science (in which he studied genetics and development, particularly in the analysis of the embryo
Regulation of transcription in mammals. An active enhancer regulatory region of DNA is enabled to interact with the promoter DNA region of its target
Regulation of transcription in mammals. An active enhancer regulatory region of DNA is enabled to interact with the promoter DNA region of its target gene by the formation of a chromosome loop. This can initiate messenger RNA (mRNA) synthesis by RNA polymerase II (RNAP II) bound to the promoter at the transcription start site of the gene. The loop is stabilized by one architectural protein anchored to the enhancer and one anchored to the promoter and these proteins are joined to form a dimer (red zigzags). Specific regulatory