The Warrego Highway is located in southern Queensland, Australia. It connects coastal centres to the south western areas of the state, and is approximately 715 km in length. It takes its name from the Warrego River, which is the endpoint of the highway. The entire highway is part of the National Highway system linking Darwin and Brisbane: formerly National Highway 54, Queensland began to convert to the alphanumeric system much of Australia had adopted in the early-2000s and this road is now designated as National Highway A2.

The Warrego River is an intermittent river that is part of the Darling catchment within the Murray–Darling basin, which is located in South West Queensland and in the Orana region of New South Wales, Australia. The Warrego River is the northernmost tributary of the Darling River.