Wesley's Chapel is a Methodist church situated in the St Luke's area in the south of the London Borough of Islington. Opened in 1778, it was built under the direction of John Wesley, the founder of the Methodist movement. The site is a place of worship and visitor attraction, incorporating the Museum of Methodism in its crypt and John Wesley's House next to the chapel. The chapel has been called "The Mother Church of World Methodism".

St Luke's is an area in London, England and is located in the London Borough of Islington. It lies just north of the border with the City of London near the Barbican Estate, and the Clerkenwell and Shoreditch areas.