West Seneca is a town in Erie County, New York, United States. The population was 45,500 at the 2020 census. West Seneca is a centrally located interior town of the county, and a suburb of Buffalo. West Seneca, Orchard Park and Hamburg form the inner "Southtowns", a cluster of middle-class suburban towns.

Buffalo is a city in the U.S. state of New York and the seat of Erie County. It lies in Western New York, at the eastern end of Lake Erie, at the head of the Niagara River, on the United States border with Canada. With a population of 278,349 according to the 2020 census, Buffalo is the 2nd largest city in New York state, 1st being New York City, and the 78th largest city in the United States. Buffalo and the city of Niagara Falls together make up the two-county Buffalo–Niagara Falls Metropolitan Statistical Area (MSA), which had an estimated population of 1.2 million in 2020, making it the 49th-largest MSA in the United States.