The Western Zone is a zone in the Tigray Region of Ethiopia. It is subdivided into three woredas (districts); from north to south they are Kafta Humera, Welkait and Tsegede. The largest town is Humera. The Western Zone is bordered on the east by the North Western Zone, the south by the Amhara Region, the west by Sudan and on the north by Eritrea. Starting from the late 17th C., internal boundaries are clearly shown, with 37 maps displaying a boundary that is located well south of the Tekeze River, or even south of the Simien mountains. Welkait is explicitly included within a larger Tigray confederation ; it is briefly mapped as part of Amhara in 1891-1894 and part of Gondar from 1944-1990. At other periods it appears independent or part of a larger Mezaga lowland region.

The Tigray, officially the Tigray National Regional State, is the northernmost regional state in Ethiopia. The Tigray Region is the homeland of the Tigrayan (Tegaru), Irob people and Kunama people. Its capital and largest city is Mekelle. Tigray is the fifth-largest by area, the fourth-most populous, and the fifth-most densely populated of the 11 regional states.