Wettin is a small town belonging to the municipality of Wettin-Löbejün in the Saale District of Saxony-Anhalt (Saxony-Ascania), Germany. It is situated on the River Saale, just north of Halle. It is known for Wettin Castle, the ancestral seat of the House of Wettin, the former ruling dynasty of Saxony, Poland, the United Kingdom, Belgium, and Bulgaria. The town and its name are of Slavic origin.

The Saale, also known as the Saxon Saale and Thuringian Saale, is a river in Germany and a left-bank tributary of the Elbe. It is not to be confused with the smaller Franconian Saale, a right-bank tributary of the Main, or the Saale in Lower Saxony, a tributary of the Leine.