Whitemud Drive is a major east–west freeway in southern Edmonton, Alberta, that stretches from 231 Street at the western city limit to Anthony Henday Drive just east of Edmonton in Strathcona County. The portion in southeast Edmonton from Anthony Henday Drive to Calgary Trail / Gateway Boulevard is designated as Highway 14, and from there until Anthony Henday Drive in west Edmonton is designated as Highway 2. The portion of Whitemud Drive from 170 Street and 75 Street forms part of the Edmonton inner ring road.

Alberta Provincial Highway No. 2, commonly referred to as Highway 2 or the Queen Elizabeth II Highway, is a major highway in Alberta that stretches from the Canada–United States border through Calgary and Edmonton to Grande Prairie. Running primarily north to south for approximately 1,273 kilometres (791 mi), it is the longest and busiest highway in the province carrying more than 170,000 vehicles per day near Downtown Calgary. The Fort Macleod—Edmonton section forms a portion of the CANAMEX Corridor that links Alaska to Mexico. More than half of Alberta's 4 million residents live in the Calgary–Edmonton Corridor created by Highway 2.