William Mullins and his family traveled as passengers on the historic 1620 voyage to America on the Pilgrim ship Mayflower. He was a signatory to the Mayflower Compact. Mullins perished in the pilgrims' first winter in the New World, with his wife and son dying soon after.

Mayflower was an English sailing ship that transported a group of English families, known today as the Pilgrims, from England to the New World in 1620. After 10 weeks at sea, Mayflower, with 102 passengers and a crew of about 30, reached what is today the United States, dropping anchor near the tip of Cape Cod, Massachusetts, on November 21 [O.S. November 11], 1620.