William Smith Clark was an American professor of chemistry, botany, and zoology; a colonel during the American Civil War; and a leader in agricultural education. Raised and schooled in Easthampton, Massachusetts, Clark spent most of his adult life in Amherst, Massachusetts. He graduated from Amherst College in 1848 and obtained a doctorate in chemistry from Georgia Augusta University in Göttingen in 1852. He then served as professor of chemistry at Amherst College from 1852 to 1867. During the Civil War, he was granted leave from Amherst to serve with the 21st Regiment Massachusetts Volunteer Infantry, eventually achieving the rank of colonel and the command of that unit.

Amherst is a city in Hampshire County, Massachusetts, United States, in the Connecticut River valley. Amherst has a council–manager form of government, and is considered a city under Massachusetts state law. Amherst is one of several Massachusetts municipalities that have city forms of government but retain "The Town of" in their official names. At the 2020 census, the population was 39,263, making it the highest populated municipality in Hampshire County. The town is home to Amherst College, Hampshire College, and the University of Massachusetts Amherst, three of the Five Colleges.