State Trunk Highway 29 is a state highway running east–west across central Wisconsin. It is a major east–west corridor connecting the Twin Cities and the Chippewa Valley with Wausau and Green Bay. A multi-year project to convert the corridor to a four-lane freeway or expressway from Elk Mound to Green Bay was completed in 2005. The remainder of WIS 29 is two-lane surface road or urban multi-lane road.

U.S. Highway 10 (US 10) in Wisconsin runs east–west across the central part of the state. It runs from the Prescott Drawbridge over the St. Croix River at Prescott east to the dock in Manitowoc where SS Badger crosses Lake Michigan to Ludington, Michigan. The highway is also designated as the Vietnam War Veterans Memorial Highway for its entire length.