Wrangell–St. Elias National Park and Preserve is an American national park and preserve managed by the National Park Service in south central Alaska. The park and preserve were established in 1980 by the Alaska National Interest Lands Conservation Act. The protected areas are included in an International Biosphere Reserve and are part of the Kluane/Wrangell–St. Elias/Glacier Bay/Tatshenshini-Alsek UNESCO World Heritage Site. The park and preserve form the largest area managed by the National Park Service with a total of 13,175,799.07 acres, an expanse larger than nine U.S. states and around the same size as Bosnia and Herzegovina or Croatia. 8,323,147.59 acres are designated as the national park, and the remaining 4,852,652.14 acres are designated as the preserve. The area designated as the national park alone is larger than the 47 smallest American national parks combined and is more than twice the size of all but two other national parks. Its area makes up over 15% of all national park designated land in the United States.

There are 21 protected areas of the United States designated as national preserves. They were established by an act of Congress to protect areas that have resources often associated with national parks but where certain natural resource-extractive activities such as hunting and mining may be permitted, provided their natural values are preserved. The activities permitted in each national preserve vary depending on the enabling legislation of the unit. All national preserves are managed by the National Park Service (NPS) as part of the National Park System.